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KMID : 0385019850010010001
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Korean Journal of Laboratory Animal Science
1985 Volume.1 No. 1 p.1 ~ p.5
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Animal Models of Type I(insulitisassociated) Diabetes
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TARUI, Seiichiro
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Abstract
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ASince von Mering and Minkowsky first demonstrated the occurrence of severe diabetes after fatal pancreatectomy in dogs, animals have served as models of human diabetes it~the need for more research into the etiology and pathogenesis of complications of this disease.
From the etiapathological viewpoint human diabetes should be classified into at least two types, Type I and Type II, Evidence hay accumulated indicating that Type 1 diabetes is closely associated with autoimmune insulitis and that various combination of resis ◎ to the action of insulin and reduced capacity to produce enough insulin results in T◎ diabetes.
In the present paper an emphasis is placed on the pathogenesis of Type I diabe A sequential changes in subsets of mononuclear cells infiltrating the islets in au◎mmune insulitis in model animals and the preventive affect of nicotinamide on the occurrence of diabetes in NOD mouse.
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KEYWORD
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